Dr. Bauyrzhan Kamalovich Otarbaev
Kazakh National Agrarian Research University
Kazakhstan
Abstract Title: Rhodococcus equi as an Infection in Goats: Pathological Findings
Biography:
Bauyrzhan Kamalovich Otarbaev, candidate of Veterinary Sciences, Associate Professor. He has graduated from the Veterinary Faculty of the Alma-Ata Zooveterinary Institute in 1995. ?? defended his Candidate’s dissertation at the Department of Microbiology and Infectious Diseases at the Kazakh National Agrarian University (KazNAU) in 2004. Since 1995, he has worked in scientific and educational institutions, progressing from junior research fellow to Associate Professor at the Department of Biological Safety. He has participated in several scientific projects focused on young livestock preservation, epizootic safety, and livestock development. His research interests include microbiology, biopreparations, diagnosis, and prevention of animal diseases. Author of over 70 scientific publications, including a monograph, textbooks, and patents. He is currently an Associate Professor in the Department of Biological Safety at the Kazakh National Agrarian Research University.
Research Interest:
Rhodococci are aerobic, Gram-positive, pleomorphic, and nonmotile bacteria that are found in soil and thrive on the simple nutrients provided by herbivore manure. Foals become infected when they ingest or inhale soil, dust, or fecal particles containing the bacteria during the first few days of life. Inhalation of virulent R. equi aerosols from the environment and intracellular replication in alveolar macrophages are important components of the pathogenesis of R. equi pneumonia in foals. Virulence in foals is associated with the presence of plasmids. The aim of our research was to examine the pathological changes in goats inoculated with different Rhodococcus equi plasmids to create a foal model. An experimental study of rhodococcosis was conducted on Saanen goats weighing 16-22 kg, divided into 4 groups of 3 animals each. Animals in the first group were administered R.equi without plasmids, the second group received R.equi VapB, and the third group received R.equi VapN intravenously at a dose of 7 ml. Control animals did not receive the drug. At the end of the observation period (50 days), all animals were killed and subjected to postmortem examination. Animals in the experimental and control groups were maintained under identical housing and feeding conditions throughout the study period. No postmortem differences were observed between animals in the first group and those in the control group. Animals in the second and third groups showed marked enlargement of the mesenteric and mediastinal lymph nodes, degenerative changes in the parenchymal organs, and inflammation of the small intestine.